Registered Nurse Jobs in Sioux Falls, SD

140 live registered nurse jobs in Sioux Falls, SD, updated daily from hospitals and health systems. Every listing links to the employer's own application, or you can apply with Betterleap and chat with a recruiter.

1. Registered Nurse (RN) | OR/Surgery | Avera Specialty Hospital — Avera Health · Sioux Falls, SD · Full-time
2. Registered Nurse - RN - Orthopedics & Sports Medicine Clinic — Sanford Health · Sioux Falls, SD · Full-time
3. RN Triage - Registered Nurse - 32nd & Ellis Family Medicine Clinic - PT Days — Sanford Health · Sioux Falls, SD · Part-time
4. Registered Nurse (RN) Visit Nurse | Home Hospice PRN — Avera Health · Sioux Falls, SD · Part-time
5. RN Coordinator - Transfer Center — Avera Health · Sioux Falls, SD · Full-time
6. RN Traveler -Surgical Trauma — Sanford Health · Sioux Falls, SD · Full-time
7. RN Traveler- Medical Cardiopulmonary/Pulmonary Acute — Sanford Health · Sioux Falls, SD · Full-time
8. Registered Nurse (RN) | Recovery — Avera Health · Sioux Falls, SD · Full-time
9. RN - Registered Nurse - Medical Cardiopulmonary & Pulmonary Acute - Weekend Days — Sanford Health · Sioux Falls, SD · Full-time
10. Registered Nurse (RN) | Pediatric Specialty Clinic GI float — Avera Health · Sioux Falls, SD · Part-time
11. RN Traveler-Medical Cardiopulmonary/Pulmonary Acute — Sanford Health · Sioux Falls, SD · Full-time
12. RN New Grad December 2026 — Avera Health · Sioux Falls, SD · Full-time
13. RN Traveler -Ortho/Neuro — Sanford Health · Sioux Falls, SD · Full-time
14. Manager, RN Inpatient - OR - Full Time — Sanford Health · Sioux Falls, SD · Full-time
15. RN - Inpatient Mixed Acuity — Avera Health · Sioux Falls, SD · Full-time
16. RN Traveler -Central Resource Pool — Sanford Health · Sioux Falls, SD · Full-time
17. RN Traveler- Medical Cardiopulmonary/Pulmonary Acute — Sanford Health · Sioux Falls, SD · Full-time
18. Registered Nurse (RN - III) | Emergency Department — Avera Health · Sioux Falls, SD · Full-time
19. Supervisor - Registered Nurse | Behavioral Health Senior Unit — Avera Health · Sioux Falls, SD · Full-time
20. RN Traveler -Cardiology — Sanford Health · Sioux Falls, SD · Full-time